FIGURE

Figure 6

ID

ZDB-FIG-211029-110

Publication

Crouzier et al., 2021 - Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish

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Figure 6

Analysis of mitochondrial respiration by the zebrafish larvae at 5 dpf analyzed using the Seahorse XF mito stress test. (A) Seahorse diagram depicting profile of oxygen consumption rate (OCR) during the assay. Letters (B–F) indicate the OCR components detailed in panels (B–F). (B) Basal respiration, (C) ATP production, (D) maximal respiration, (E) proton leak, (F) non-mitochondrial respiration. Data are shown as mean ± SEM from the number of larvae indicated in (B). Abbreviations: Oligom, oligomycin (25 μM); FCCP, carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (8 μM); Rot/Anti A, rotenone + antimycin A (15 μM). * p < 0.05, ** p < 0.01; unpaired t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sigmar1^f19/f19
Observed In:	ATP biosynthetic process cellular respiration regulation of mitochondrial ATP synthesis coupled proton transport
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.