FIGURE

Figure 5

ID
ZDB-FIG-211001-9
Publication
Ali et al., 2021 - Met is required for oligodendrocyte progenitor cell migration in Danio rerio
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Figure 5

met mutants exhibit reduced OPC proliferation. (A) Transverse sections of 76 hpf olig2:egfp;sox10:mrfp met+/+ and metuva38/uva38 larvae. Open yellow arrowheads denote sox10+/olig2+ OPCs. Dashed yellow circle denotes boundary of the spinal cord. (B–E) Quantifications of olig2+/sox10+ OLCs from ten sequential 20 μm sections of 76 hpf olig2:egfp;sox10:mrfp met+/+ (n = 7), met+/uva38 (n = 6), and metuva38/uva38 (n = 6) larvae. Mean with SEM. Statistical test: one-way ANOVA with Tukey’s Multiple Comparison Test. (F) EdU treatment paradigm and lateral view spinal cord images of 74 hpf sox10:mrfp;met+/+ and metuva38/uva38 zebrafish larvae. Magenta-outlined yellow arrowheads denote sox10+/EdU+ OPCs. Magenta open arrowheads denote sox10+/EdU OLCs. Yellow open arrowheads denote sox10/EdU+ cells. Yellow dashed line denotes ventral edge of the spinal cord. (G) Quantifications of sox10+/EdU+ OLCs from spinal cord images of 76 hpf sox10:mrfp EdU labeled met+/+ (n = 7), met+/uva38 (n = 8), and metuva38/uva38 (n = 7) larvae. Mean with SEM. Statistical test: one-way ANOVA with Tukey’s Multiple Comparison Test. Scale bars (A) 10 μm, (F) 20 μm.

Expression Data
Genes:
Fish:
Anatomical Term:
Stage: Protruding-mouth

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Protruding-mouth

Phenotype Detail
Acknowledgments
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