FIGURE

FIGURE 5

ID

ZDB-FIG-210902-29

Publication

Koh et al., 2021 - Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy

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FIGURE 5

Summary of FCS observations. (A) Freely diffusing mCherry. (B) Two components of freely diffusing mCherry-Smn and mCherry-Smn with endogenous Smn in complexes that are distinct for cell body and axon (oligomers of mCherry-Smn and Smn are indicated by tetramers). (C) Truncated eGFP-Smn concentrates in nucleus, freely diffuses in cytoplasm. Complexes consist of only endogenous Smn. (D) Depletion of endogenous Smn led to a depletion of freely diffusing mCherry-Smn and mCherry-Smn replacing endogenous Smn in complexes. For details, see main text.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol