FIGURE

FIGURE 4

ID

ZDB-FIG-210902-28

Publication

Koh et al., 2021 - Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy

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FIGURE 4

Expression and dynamics of eGFP- Smn Δex6,7 in zebrafish motor neurons. (A) Expression of eGFP- SmnΔex6,7 in motor neuron cell body and axon at 2 dpf. It is expressed strongly in the nucleus and weakly in axon and cytoplasm of cell body. (B) Representative ACF and fitted ACF of eGFP, eGFP-Smn and eGFP-SmnΔex6,7. (C) Average diffusion coefficients, D₁ (μm²/s) of eGFP, eGFP-Smn, eGFP-SmnΔex6,7 in cell body. (D) Average diffusion coefficients, D₂ (μm²/s) of eGFP-Smn, eGFP-SmnΔex6,7 in cell body. (E) Average diffusion coefficients, D₁ (μm²/s) of eGFP, eGFP-Smn, eGFP- SmnΔex6,7 in axons. (F) Average diffusion coefficients, D₂ (μm²/s) of eGFP-Smn, eGFP-SmnΔex6,7 in axons. Error bars represent the SD. (^n.s.P > 0.05, ^∗P < 0.05, ^∗∗∗P < 0.001). Measurements grouped under Case 1 were fitted to 3D 1-particle diffusion model, found in 6 out of 14 measurements, indicating a loss of the second component. Case 2 refers to measurements fitted to 3D 2-particle diffusion model, found in 8 out of 14 measurements. The numbers above the graph indicate the numbers of fish (number of points) the measurements were taken in.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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