FIGURE

Fig 3

ID

ZDB-FIG-210802-15

Publication

Wen et al., 2021 - The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics

Other Figures

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Fig 3

Transcription factor <italic toggle='yes'>klf6a</italic> regulates CV pruning in zebrafish.

(A) Generation of KI (klf6a -HA-P2A-gal4) fish. (B) Expression pattern of KI(klf6a-HA-P2A-gal4) fish. Arrowheads indicate the location of klf6a at the vasculature. (C) Role of klf6a in CV pruning in zebrafish embryos. Boxes show enlarged images of the CV. The arrowhead indicates the unpruned vessel. Scale bar: 50 μm. (D) Quantification of vascular loops in the sibling and klf6a^-/-: sibling, n = 23 embryos; klf6a^-/-, n = 13 embryos. P < 0.001. Student’s unpaired two-tailed t test.

Expression Data

Genes:	DsRed EGFP GFP mCherry
Fish:	s843Tg; sd2Tg klf6a^cqu3/cqu3; s843Tg; sd2Tg klf6a^cqu4Tg; c369Tg; ci5Tg
Anatomical Terms:	caudal vein plexus caudal vein plexus nucleate erythrocyte
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	klf6a^cqu3/cqu3; s843Tg; sd2Tg
Observed In:	caudal vein plexus venous blood vessel morphogenesis
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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