FIGURE

Figure 6

ID

ZDB-FIG-210702-6

Publication

Buchberger et al., 2021 - A novel inhibitor rescues cerebellar defects in a zebrafish model of Down Syndrome-associated kinase Dyrk1A overexpression

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Figure 6

Novel tank diving test reveals anxiety-like behavior in adult Tg(Car8-hDryk1A-mClover) fish.A–F, swimming behavior of adult WT (n = 14) and PC-Dyrk1A fish (n = 10) examined in the novel tank diving test. The number of zone transitions (A, two-tailed unpaired t test, p = 0.003), the time in the top part (B, nonparametric t test, p = 0.0015), the distance covered (C, two-tailed unpaired t test, p < 0.0001), and the speed (D, two-tailed unpaired t test, p < 0.0001) were determined in 6-min recordings. All parameters analyzed were significantly reduced in PC-Dyrk1A fish. E and F, representative tracks of a control (E) and PC-Dyrk1A zebrafish with bottom (light blue) and top part (light gray) of the tank. Means ± SD. The scale bar represents 3 cm. Dyrk1A, dual-specificity tyrosine phosphorylation–regulated kinase 1A; PCs, Purkinje cells. ∗∗p < 0.01, ∗∗∗∗p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bz19Tg
Observed In:	swimming
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.