FIGURE

Figure 4

ID

ZDB-FIG-210702-4

Publication

Buchberger et al., 2021 - A novel inhibitor rescues cerebellar defects in a zebrafish model of Down Syndrome-associated kinase Dyrk1A overexpression

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Figure 4

hDyrk1A overexpression in PCs compromises swimming behavior.A–D, swimming activity of 5 dpf WT and heterozygous PC-Dyrk1A larvae; mean values ±SD of 30 min tracks. A, PC-Dyrk1A larvae swam significantly shorter distances than WT larvae (two-tailed unpaired t test, p = 0.022) and B, consequently displayed a reduced average swim speed (two-tailed unpaired t test, p = 0.0041). C, the distance swum with slow movements (0.2< slow speed <21 mm/s) was significantly decreased (two-tailed unpaired t test, p = 0.0228) in PC-Dyrk1A larva (D) as was the distance covered by fast movements (fast speed >21 mm/s, nonparametric t test p = 0.0385). The number of movements was significantly decreased in PC-Dyrk1A larva (E, two-tailed unpaired t test, p = 0.0012), whereas the period of activity was almost equal in both groups (F, nonparametric t test, ns, p = 0.0612). All values are the means ± SD (error bars). WT: n = 44; PC-Dyrk1A: n = 50; ∗p < 0.05; ∗∗p < 0.02; ∗∗∗p < 0.005. dpf, days post fertilization; Dyrk1A, dual-specificity tyrosine phosphorylation–regulated kinase 1A; ns, not significant; PCs, Purkinje cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bz19Tg
Observed In:	swimming
Stage:	Day 5

Phenotype Detail

Acknowledgments

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