FIGURE

Figure 6

ID

ZDB-FIG-210611-62

Publication

Crouzier et al., 2021 - Loss of Pde6a Induces Rod Outer Segment Shrinkage and Visual Alterations in pde6a^Q70X Mutant Zebrafish, a Relevant Model of Retinal Dystrophy

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Figure 6

Analysis of rods in pde6a^Q70X zebrafish during development. Representative confocal images of the retina of pde6a^WT and pde6a^Q70X zebrafish obtained after immunostaining of rods with a Rho4d2 antibody highlighting Rhodopsin (red) at 5 dpf (A) and 21 dpf (B). The nuclei were counterstained with DAPI (blue). Scale bar = 30 μm. (C,D) Quantification of the total area of rod outer segments normalized against the length of the retinal section, based on three independent measurements of larvae per group at 5 dpf (C) and 21 dpf (D). The number of animals is indicated within the columns. ^∗p < 0.05, ^∗∗p < 0.01.

Expression Data

Gene:	rho
Antibody:	Ab5-rho
Fish:	AB pde6a^{sa14581/sa14581} (AB)
Anatomical Term:	retinal rod cell rod photoreceptor outer segment
Stage Range:	Day 5 to Days 21-29

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pde6a^{sa14581/sa14581} (AB)
Observed In:	retinal rod cell rod photoreceptor outer segment
Stage Range:	Day 5 to Days 21-29

Phenotype Detail

Acknowledgments

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