FIGURE

Fig. 8

ID

ZDB-FIG-210519-94

Publication

Tseng et al., 2021 - The role of Niemann-Pick type C2 in zebrafish embryonic development

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Fig. 8

(A) Live imaging of 30 hpf wild-type embryos treated with the indicated dose of U18666A starting at 4 hpf. U18666A-treated embryos exhibited a dose-dependent phenotype ranging from smaller otoliths at 24 μM to no otoliths, abnormal head, no circulating blood cells, and curved/twisted body axis at 96 μM. Arrowheads indicate the otic vesicle. Scale bars: 500 μm (whole embryo); 200 μm (otic vesicle). (B) Measurement of otolith diameters from DMSO- and U18666A-treated wild-type embryos at 30 hpf. n=118 (DMSO), 118 (24 μM), 114 (48 μM) and 94 (96 μM) (n=2 experiments). Two otoliths per embryo were measured. 0 indicates that otolith was not detectable. P<0.0001 for each treatment group compared with DMSO (Kruskal–Wallis test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	EKW
Condition:	chemical treatment: amphiphile
Observed In:	blood circulation brain head otolith post-vent region
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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