FIGURE

Figure 1

ID

ZDB-FIG-210409-150

Publication

Kim et al., 2021 - Comparative Proteome Research in a Zebrafish Model for Vanishing White Matter Disease

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Figure 1

Zebrafish eif2b3 knockout model for VWM disease. (A) Visualization of myelination using Tg (mbp:mGFP) crossed with eif2b3−/− zebrafish at 5 dpf. Myelination defects in eif2b3^−/− which recapitulate phenotypes of VWM disease. (B) Whole-mount in situ hybridization with myelin development markers, mbp, olig2, and nestin in eif2b3^−/− zebrafish. mbp, myelin basic protein; oilg2, oligodendrocyte transcription factor; nestin, early neural stem/progenitor cell marker. Arrow indicates ectopic expression of nestin in the midbrain region. R, retina.

Expression Data

Genes:	mbpa nes olig2
Fish:	eif2b3^{ck156a/ck156a}
Anatomical Terms:	central nervous system glial cell (sensu Vertebrata) midbrain neuronal stem cell nervous system myelin sheath
Stage Range:	Protruding-mouth to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eif2b3^{ck156a/ck156a} eif2b3^{ck156a/ck156a}; ck5Tg
Observed In:	central nervous system glial cell (sensu Vertebrata) midbrain neuronal stem cell myelination nervous system myelin sheath
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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