Fig. 5

Figure 5. A Proposed Model of LRP5 Function in the Visual Cycle LRP5 protein (shown in orange in right bottom) is a strong candidate for the receptor of atROL by forming a complex with RBP1 protein (the transporter of atROL, shown in light green in right bottom) and may be involved in the uptake of atROL in the RPE in the visual cycle. The flow of retinoids is shown by red arrows and the unknown possible interactions are indicated with “?”. atROL, all-trans retinol; ABCA4, ATP binding cassette subfamily A member 4; IRBP, inter-photoreceptor retinol binding protein (also known as RBP3, retinol binding protein 3); LRAT, lecithin retinol acyltransferase; LRP5, LDL receptor related protein 5; RBP1, retinol binding protein 1 (also known as CRBP, cellular retinol binding protein); RDH, retinol dehydrogenase; RLBP1, retinaldehyde binding protein 1 (also known as CRALBP, cellular retinal binding protein); RPE65, retinoid isomerohydrolase RPE65; STRA6, stimulated by retinoic acid gene 6.