FIGURE

Figure 3

ID

ZDB-FIG-201116-10

Publication

Whittle et al., 2020 - MYH3-associated distal arthrogryposis zebrafish model is normalized with para-aminoblebbistatin

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Figure 3

The <italic>smyhc1</italic><sup>R673H</sup> allele reduces survival in a dose‐dependent manner

Schema of in‐crosses used to generate clutches for survival assay.

The predicted mendelian (1:2:1) and experimental ratio of genotypes of progeny from smyhc1^R673H/+ in‐crosses demonstrates survival at the indicated ages. This ratio quickly skewed toward an overrepresentation of smyhc1^+/+ fish with no representation of smyhc1^R673H/R673H after 5 dpf. There is also dropout of smyhc1^R673H/+ fish into adulthood. Number of fish counted per group is indicated.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smyhc1^{stl582/stl582} smyhc1^stl584/+
Observed In:	whole organism
Stage Range:	Long-pec to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.