FIGURE

FIGURE 7

ID

ZDB-FIG-201007-20

Publication

Wang et al., 2020 - A Mutation in VWA1, Encoding von Willebrand Factor A Domain-Containing Protein 1, Is Associated With Hemifacial Microsomia

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FIGURE 7

Knockdown of vwa1 leads to disorganization of pharyngeal chondrocytes at 4 dpf. (A) In uninjected control embryos at 4 dpf, craniofacial cartilage had formed and showed a very stereotypic shape between individuals, exhibiting the characteristic “stack of pennies” organization in which thin and elongated chondrocytes are assembled on top of one another to form their respective cartilage element. (B) In vwa1 morphants, the size and length-width ratio of many cartilage chondrocytes were smaller and the cartilage elements were greatly deformed compared with those of uninjected controls.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-vwa1 + MO4-tp53
Knockdown Reagents:	MO1-vwa1 MO4-tp53
Observed In:	pharyngeal arch chondrocyte
Stage:	Day 4

Phenotype Detail

Acknowledgments

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