FIGURE

Figure 4

ID

ZDB-FIG-201003-245

Publication

Vishnolia et al., 2020 - Studies in Zebrafish Demonstrate That CNNM2 and NT5C2 Are Most Likely the Causal Genes at the Blood Pressure-Associated Locus on Human Chromosome 10q24.32

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Figure 4

Graphs represents blood flow parameters measured after downregulation of as3mt, borcs7, cnnm2a, cnnm2b, cyp17a1, nt5c2a, and nt5c2b genes in zebrafish using transcriptional splice modification morpholinos. Blood flow (nL/sec), arterial pulse (beats per minute) and linear velocity (μM/sec) compared against their respective control groups. Data was generated from n = 9 larvae per groups, error bars represents standard deviation and significance was set at p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-as3mt AB + MO1-borcs7 AB + MO1-nt5c2a AB + MO1-nt5c2b AB + MO2-cnnm2a AB + MO2-cnnm2b AB + MO2-cyp17a1
Knockdown Reagents:	MO1-as3mt MO1-borcs7 MO1-nt5c2a MO1-nt5c2b MO2-cnnm2a MO2-cnnm2b MO2-cyp17a1
Observed In:	blood blood circulation heart contraction
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cardiovasc Med