FIGURE

Fig. 6

ID

ZDB-FIG-200722-13

Publication

Schlegel et al., 2019 - A New Zebrafish Model for CACNA2D4-Dysfunction

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Fig. 6

Ribeyeb expression in cacna2d4-KO lines. (A) Ribeyeb expression levels in the OPL of 5 dpf, 20 dpf and adult retina are not affected by mutations in cacna2d4 genes. However, both cacna2d4b-KO and double-KO show ectopic Ribeyeb staining distal to the OPL at all ages examined. (B) mGluR6b expression is comparable to WT in all KO lines.

Expression Data

Genes:	ctbp2l grm6b
Antibodies:	Ab1-grm6b Ab2-ctbp2l
Fish:	TU cacna2d4a^zh5/zh5 (TU) cacna2d4b^zh6/zh6 (TU) cacna2d4a^zh5/zh5; cacna2d4b^zh6/zh6 (TU)
Anatomical Terms:	retinal outer plexiform layer retinal photoreceptor layer
Stage Range:	Day 5 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cacna2d4b^zh6/zh6 (TU) cacna2d4a^zh5/zh5; cacna2d4b^zh6/zh6 (TU)
Observed In:	retinal photoreceptor layer
Stage Range:	Day 5 to Adult

Phenotype Detail

Acknowledgments

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