FIGURE

Fig. 6.

ID

ZDB-FIG-200509-40

Publication

Veerman et al., 2019 - Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I_K,ACh)

Other Figures

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Fig. 6.

ACh induces more pronounced effects in S81L^homo compared to WThuman SAN pacemaker cells in computer simulations. (A-C) Spontaneous APs (blue lines) and associated net membrane current (I_net, gray lines), hyperpolarization-activated ‘funny current’ (I_f, green lines) and I_K,ACh (red lines) in a WT human SAN pacemaker cell at baseline (A), upon addition of 10 nmol l⁻¹ ACh (B) and upon addition of 10 nmol l⁻¹ ACh in the presence of XEN-R0703 (C). (D-F) Spontaneous APs and associated I_net, I_f and I_K,ACh in an S81L^homo human SAN pacemaker cell at baseline (D), upon addition of 10 nmol l⁻¹ ACh (E) and upon addition of 10 nmol l⁻¹ ACh in the presence of XEN-R0703 (F).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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