FIGURE

Fig. 1

ID

ZDB-FIG-200413-39

Publication

Villasenor et al., 2019 - Hhex regulates the specification and growth of the hepatopancreatic ductal system

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Fig. 1

hhex−/− display impaired liver and pancreas development. (A–C) Analysis of the endodermal phenotypes in hhex−/−. (A) Lateral views of 96 hpf Tg(fabp:GFP) hhex+/+ sibling and hhex−/− larvae. (B) Maximum intensity projections of 96 hpf hhex+/+ sibling and hhex−/− larvae. Ventral views, anterior to the top. hhex−/− display impaired liver development. (C) Dorsal views of whole-mount in situ hybridization for ptf1a expression at 32 and 72 hpf. Compared to stage-matched hhex+/+ siblings, hhex−/− lack exocrine tissue specification, but they display ptf1a neural expression. Black arrows point to pancreatic exocrine tissue. H, heart; L, liver; P, pancreas. Scale bars: 50 μm.

Expression Data

Gene:	ptf1a
Fish:	WT hhex^s721/s721
Anatomical Terms:	brain exocrine pancreas intestinal bulb primordium
Stage Range:	Prim-15 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hhex^s721/s721 hhex^s721/s721; as3Tg hhex^s721/s721; nim5Tg
Observed In:	exocrine pancreas intestinal bulb primordium liver pancreas
Stage Range:	Prim-15 to Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 458(2), Villasenor, A., Gauvrit, S., Collins, M.M., Maischein, H.M., Stainier, D.Y.R., Hhex regulates the specification and growth of the hepatopancreatic ductal system, 228-236, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.