FIGURE

Figure 5

ID

ZDB-FIG-200314-21

Publication

Grzegorski et al., 2020 - Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish

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Figure 5

Loss of prothrombin results in early lethality due to hemorrhage. (A) Survival curve demonstrating significant mortality by 2 months of age in f2^−/− siblings, log-rank (Mantel-Cox) analysis. (B) Examples of grossly visible intracranial, intramuscular, and fin bleeds (arrows). (C) Histological sections of wild-type and f2^−/− siblings demonstrated microscopic bleeds in the brain, jaw, heart, muscle, and fins. Arrows point to pools of erythrocytes and unaffected comparable tissue in the control.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	f2^{mi4008/mi4008} (AB/TL)
Observed In:	brain whole organism
Stage Range:	Days 30-44 to Days 45-89

Phenotype Detail

Acknowledgments

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