ZFIN Image: Grzegorski et al., 2020, Figure 5

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Figure 5

Loss of prothrombin results in early lethality due to hemorrhage. (A) Survival curve demonstrating significant mortality by 2 months of age in f2^−/− siblings, log-rank (Mantel-Cox) analysis. (B) Examples of grossly visible intracranial, intramuscular, and fin bleeds (arrows). (C) Histological sections of wild-type and f2^−/− siblings demonstrated microscopic bleeds in the brain, jaw, heart, muscle, and fins. Arrows point to pools of erythrocytes and unaffected comparable tissue in the control.

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Acknowledgments

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