FIGURE

Fig. S2

ID

ZDB-FIG-200313-2

Publication

James et al., 2019 - Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism

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Fig. S2

Figure S2 a Transverse 5μm section of adult WT upper intestinal tissue stained with alcian blue and Eosin B (n=6 for WT, n=6 for shank3abΔC +/- and n=6 for shank3abΔC -/-). b 40x magnification shows dense plicae that extend to the point of nearly occluding the luminal space. c,d In shank3abΔC +/- upper intestinal tissue, increased counts of goblet cells (black arrowheads) suggest inflammation. e,f Homozygous shank3abΔC -/- adults also show increased goblet cell count. Comparison of goblet cell counts in WT, shank3abΔC +/-, and shank3abΔC -/- adults show a significant increase in the number of goblet cells in both shank3abΔC +/- and shank3abΔC -/- adults. WT and shank3abΔC -/- comparison (p<0.0138) and WT and shank3abΔC +/- comparison (p<0.0015).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	shank3a^umi101/+; shank3b^umi102/+ (AB) shank3a^{umi101/umi101}; shank3b^{umi102/umi102} (AB)
Observed In:	goblet cell intestinal villus intestine intestine lumen
Stage:	Adult

Phenotype Detail

Acknowledgments

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