FIGURE

Fig. 1

ID

ZDB-FIG-200217-1

Publication

Singh et al., 2019 - αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish

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Fig. 1

Zebrafish αklotho and fgf23 Mutants

(A–F) Body condition of αklotho and fgf23 mutant males at 5 mpf: (A) Tü wild-type strain, (B) αklotho (klΔ5), and (C) fgf23 (fgf23ins1) mutant in Tü background; (D) AB wild-type strain, (E) αklotho (klΔ5), and (F) fgf23 (fgf23Δ11) mutant in AB background.

(G–J) Survival curves for (G) αklotho (n = 36 background controls, 32 mutants; p < 0.0001) and (H) fgf23 mutants (n = 14 wild-type siblings, 14 mutants; p < 0.0001) in Tü background and for (I) αklotho (n = 24 wild-type siblings, 21 mutants; p = 0.0001) and (J) fgf23 mutants (n = 60 background controls, 68 mutants; p < 0.0001) in AB background. Log-rank (Mantel-Cox) test for statistical analysis on survival curves in GraphPad Prism.

(K and L) Analysis of speed (cm) in the (K) circular arena and (L) home-tank arena. Age (m; mpf) on x axis; n = number of fish.

(M and N) αklotho mutants and wild-type controls in (M) circular and (N) home-tank arena.

(O and P) fgf23 mutants and wild-type controls in (O) circular and (P) home-tank arena. Statistical analysis using unpaired t test in GraphPad Prism.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgf23^{zf3214/zf3214} (AB) fgf23^{zf3215/zf3215} (TU) kl^{zf3212/zf3212} (TU) kl^{zf3213/zf3213} (AB)
Observed In:	eye fin swimming whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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