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Fig. 10

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ZDB-FIG-200129-20

Publication

Sun et al., 2020 - Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway

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Fig. 10

Schematic diagram for vertebral column development and proposed model for the regulation of mTORC1/TFEB pathway by DSTYK.

a The development process of notochord and vertebral column in WT and dstyk mutant (See also in “Discussion”). b Model depicting the proposed mechanistic regulation of TFEB by DSTYK. In normal cells, DSTYK could inhibit the activity of mTORC1, resulting in nuclear translocation of non-phosphorylated TFEB and promoting lysosomal and LRO genes transcription. In Dstyk-deficient cells, mTORC1 is activated and phosphorylates TFEB, resulting in reduced TFEB nuclear translocation and inhibition of lysosomal and LRO genes transcription.

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