FIGURE

Fig. 4.

ID

ZDB-FIG-191230-562

Publication

Kalasekar et al., 2019 - Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4.

Switching on additional activated β-catenin in adult zebrafish does not increase HCC penetrance. CreLox [Tg(fabp10a:CreER^T2); Tg(fabp10a:flox-pt-β-cat)] zebrafish and control siblings lacking either the Cre driver or lox-switch transgene [Tg(fabp10a:flox-pt-β-cat) and Tg(fabp10a:CreER^T2), control], were treated with 4-hydroxytamoxifen (TAM) or vehicle (ethanol, EtOH) at 3 mpf. Livers were weighed and examined microscopically 6 months later. (A) Scatter plot showing liver mass normalized to total body mass, ±s.d. P-values were obtained using ordinary one-way ANOVA followed by Sidak's multiple comparisons test. Data from four experiments were pooled. (B) Stacked bar graph showing the percentage of zebrafish per tested group categorized as no/minimal changes, intermediate changes, or HCC. P-values derived using Fisher's exact test, comparing samples with and without HCC. Data from three experiments were pooled.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s750Tg; s752Tg
Condition:	chemical treatment by environment: afimoxifene
Observed In:	liver liver hepatocellular carcinoma
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biol. Open