FIGURE

Fig. S6

ID

ZDB-FIG-190925-3

Publication

Cox et al., 2019 - The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain

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Fig. S6

Crispr/Cas9 targeting of adam19b in Tg(3.2:egfp:hsp70:nsfB-mcherry.crest) larvae expressing mCherry in motor neurons and egfp in epibranchial sensory ganglia. Panels (A–C)represent control fish: (A) shows motor neurons and axons (mV, mVII and mX; red channel:hsp70:nsfB-mcherry.crest), (B) shows epibranchial sensory ganglia (green channel:3.2:egfp; sVII, sIX and sX are the projections of the facial (gVII), glossopharyngeal (gIX) and vagus (gX) ganglia, respectively) and (C) shows a composite of both images. Panels (D–F) represent Crispr/Cas9 targeting of adam19b. Panel (D) shows unaffected mV, mVII and mX motor neurons (red channel:hsp70:nsfB-mcherry.crest), (E) shows misrouted epibranchial ganglia projections (dotted white arrow; green channel:3.2:egfp) and (F) shows a composite of both images. All images are oriented anterior to the left and dorsal at top. Scale bars = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Neural Circuits