FIGURE

Fig. S2

ID

ZDB-FIG-190821-33

Publication

Gudmundsson et al., 2019 - TAF1, associated with intellectual disability in humans, is essential for embryogenesis and regulates neurodevelopmental processes in zebrafish

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Fig. S2

Comparison of two different taf1 knockout strains. (A) Schematic overview of deletions in two different strains, taf1^{uu1931/ uu1931} p.(Gly296Leufs*2) and taf1^{uu1941/ uu1941} p.Glu362Alafs*9. (B) Four zebrafish embryos of both taf1^{uu1931/ uu1931} and taf1^{uu1941/ uu1941}at 4 days post-fertilization show a similar abnormal phenotype compared to wild-type taf1 zebrafish (left). The malformations were lethal and included general developmental delay, reduced pigmentation, underdeveloped craniofacial cartilage, cerebral edema, underdeveloped and malformed ears, dorsally bent body axis, heart edema, blood-filled cavities, short pectoral fin, and underdeveloped eyes with coloboma.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	taf1^{uu1931/uu1931} (AB) taf1^{uu1941/uu1941} (AB)
Observed In:	blood brain coelom cranial cartilage embryo development eye heart inner ear pectoral fin whole organism whole organism anterior-posterior axis
Stage:	Day 4

Phenotype Detail

Acknowledgments

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