FIGURE

Fig. 4

ID

ZDB-FIG-190722-27

Publication

Delacruz et al., 2019 - Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas

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Fig. 4

Human CNOT3 rescues intestinal defects in zebrafish apc^mcr embryos. (A) Graph shows cnot3a mRNA expression relative to 18s in 72 hpf embryos. (B) apc^mcr and wildtype embryos, WISH staining for gut marker fabp2 for vehicle and hCNOT3 injected apc^mcr embryos. (C) WISH staining for hCNOT3 E20K and E70K-injected apc^mcr embryos and vehicle-injected apc^WT. Note that the red arrowhead = fabp2 staining. (D) Percentage of apc^mcr fish with gut marker staining from (A and B) at 72 hpf (n > 10 per group). Statistical significance of CNOT3 mRNA injection rescue was determined using Fisher’s exact test compared to uninjected apc^mcr embryos alone. ns = not significant; ^*** = p-value = 0.0003; ^**= p-value = 0.0043.

Expression Data

Gene:	cnot3a
Fish:	TU apc^hu745/hu745
Anatomical Term:	whole organism
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	apc^hu745/hu745
Observed In:	whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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