FIGURE

Fig. 5

ID

ZDB-FIG-190626-60

Publication

Chrispell et al., 2018 - Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish

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Fig. 5

Recovery of the native ERG b-wave to successive stimuli in grk knockout zebrafish larvae. (A) Representative ERG waveforms of untreated, dark-adapted larvae subjected to successive stimuli using a dual flash paradigm of a 20-ms flash of saturating white light (1000 cd/m2) with an interstimulus interval (ISI) of 2 s. Vertical black dotted lines indicate the time of stimulus. (B) Data are plotted as the ratio of the maximum b-wave response amplitude of the second stimulus to that of the initial stimulus for ISIs ranging from 0.75 s to 5 s. A linear mixed model analysis of covariance found no significant effect of genotype when compared to wildtype for grk1b^−/− (F_[1,14] = 1.2; P = 0.2879) or grk7a^−/− larvae (F_[1,17] = 3.3; P = 0.0889). Error bars represent SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	grk1b^nc201/nc201 grk7a^nc200/nc200
Observed In:	retinal neural layer detection of light stimulus involved in visual perception
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.