FIGURE

Fig. 2

ID

ZDB-FIG-190606-51

Publication

San et al., 2019 - The ezh2(sa1199) mutant zebrafish display no distinct phenotype

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Fig. 2

ezh2(sa1199) zebrafish line has non-specific phenotypes.

A. Whole mount in-situ hybridization for ezh2 on 3 dpf ezh2(sa1199) (left panel) and ezh2(hu5670) (right panel) embryos. Left panel. Wild type siblings (top) show ezh2expression in the brain, eyes, branchial arches, and the gut (white arrowheads). Heterozygotes (middle) and ezh2(sa1199) mutants (bottom) show the same expression pattern; they are phenotypically comparable to wild types and have the same spatiotemporal ezh2 expression pattern. Right panel. Wild type siblings (top) show similar ezh2 expression to ezh2(sa1199) in-cross embryos (white arrowheads). Heterozygotes (middle) show decreased expression, and ezh2 is barely detectable in ezh2(hu5670) mutants (bottom). Scale bar: 500 μm. Numbers indicate the number of embryos displaying the shown expression pattern per total number of embryos tested. B. Left panel shows normal wild type and mutant embryos at 3 and 2 dpf, respectively. The right panel shows 2 and 3 dpf wild type and mutant embryos, respectively, with yolk sac, heart, and brain edemas (white arrowheads) and spinal curvatures (black arrowheads).

Expression Data

Gene:	ezh2
Fish:	WT ezh2^{hu5670/hu5670} ezh2^{sa1199/sa1199} ezh2^hu5670/+ ezh2^sa1199/+
Anatomical Terms:	brain eye gut pharyngeal arch 3-7
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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