FIGURE

Fig. 5-S1

ID

ZDB-FIG-190606-41

Publication

Pickett et al., 2018 - Cumulative mitochondrial activity correlates with ototoxin susceptibility in zebrafish mechanosensory hair cells

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Fig. 5-S1

Reduced hair cell activity does not influence hair cell turnover.

Maximum projects of (A) DMSO control and (B) benzamil-treated fish expressing hair cell-specific membrane GFP (Tg[Pou4f3:gap43-GFP]) and photoconverted, nuclear localized EOS (Tg[Atoh1a:nls-Eos]^w214) at 5dpf. (C) The ratio of red label-retaining hair cells to total number of hair cells per neuromast counted at 5dpf. There is no difference between control and treated groups, indicating that reduced MET does not lead to increased hair cell turnover. Control: 0.72 ± 0.12, n = 8 control fish; Treated: 0.70 ± 0.14, mean ratio ±SD, n = 10 fish; 2–3 neuromasts analyzed per fish; Mann-Whitney U test, p = 0.76. Asterisks indicate hair cells with label-retaining nuclei. Scale bar = 5 μm.

Expression Data

Genes:	Eos GFP
Fish:	atoh1a^w214Tg; s356tTg
Condition:	chemical treatment: Benzamil
Anatomical Terms:	neuromast hair cell neuromast hair cell membrane neuromast support cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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