FIGURE

Fig. S2

ID

ZDB-FIG-181207-31

Publication

Weger et al., 2018 - Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

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Fig. S2

Glutamine metabolism in vertebrates.

(A) Schematic illustrates glutamate metabolism in humans. (B) Phylogenetic analysis of the glutamine synthetase (GLUL) and glutaminase (GLS, GLS2) proteins in human (h), mouse (m), rat (r) and zebrafish (dr). Aminoacylase 1 (ACY1) and aldolase A (ALDOA) were used as outgroups. (C) Reanalysis of a previously published RNA-seq study (1) showing expression of the zebrafish glutaminases (gls2a, gls2b, gls3, glsa, glsb) and glutamine synthetase genes (glula, glulb, glulc) in wild-type embryos/larvae during development. Abbreviations: epi, epiboly; som, somites; prim, primordium; prot, protruding; hpf, hours post-fertilization. (D) Whole-mount in situ hybridization of the glutaminase transcripts (gls2a, gls2b, gls3, glsa, glsb) in wild-type larvae at 120 hpf. Images are a representative example of the whole-mount in situ hybridization stainings (n = 20). Scale-Bar: 0.2 mm.

Expression Data

Genes:	gls2a gls2b glsa glsb glsl
Fish:	WT
Anatomical Terms:	brain intestine liver swim bladder
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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