Gene

glsa

ID

ZDB-GENE-050204-3

Name

glutaminase a

Symbol

glsa Nomenclature History

Previous Names

glsl

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Is expressed in brain; pectoral fin; and swim bladder. Orthologous to human GLS (glutaminase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With glsa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 71	Alliance	Developmental and epileptic encephalopathy 71	618328
		Global developmental delay, progressive ataxia, and elevated glutamine	618412
		?Infantile cataract, skin abnormalities, glutamate excess, and impaired intellectual development	618339

Associated With glsa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR041541	Glutaminase, EF-hand domain
Family	IPR015868	Glutaminase
Homologous_superfamily	IPR012338	Beta-lactamase/transpeptidase-like
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat