FIGURE

Fig. 4

ID

ZDB-FIG-180829-8

Publication

Chen et al., 2018 - Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish

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Fig. 4

Effects of HC, HF, and EF diets treatment on autophagy. (A) LC3 puncta formation in liver of GFP-LC3 transgenic zebrafish larvae fed with control, HC, HF, and EF diets. Bar = 100 μm. (B) Quantification of LC3 puncta abundance in (A) with software Image J. (C) The genes expression involved in autophagy (n = 4). (D) The protein expression of LC3BII, ATG3, and p62 were detected by western blot in liver of zebrafish larvae fed with control, HC, HF, and EF diets (n = 4) *P < 0.05, **P < 0.01 vs. control. (E) Autophagy pathway in HC group by KEGG. Genes with red-filled are up-regulated, while genes with green-filled are down-regulated.

Expression Data

Genes:	atg3 atg5 atg7 atg12 map1lc3b sqstm1
Antibodies:	Ab1-atg3 Ab1-map1lc3b Ab4-sqstm1
Fish:	AB
Conditions:	increased food availability high cholesterol high fructose
Anatomical Term:	liver
Stage:	Days 14-20

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB zf155Tg
Conditions:	increased food availability high cholesterol high fructose
Observed In:	liver liver autophagosome
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

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