Gene
atg7
- ID
- ZDB-GENE-030131-1633
- Name
- ATG7 autophagy related 7 homolog (S. cerevisiae)
- Symbol
- atg7 Nomenclature History
- Previous Names
-
- fb76g05
- im:7158252
- wu:fb76g05
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin-like modifier activating enzyme activity. Acts upstream of or within autophagosome assembly; heart development; and mitophagy. Predicted to be located in cytoplasm. Is expressed in brain; liver; male organism; and muscle. Human ortholog(s) of this gene implicated in autosomal recessive cerebellar ataxia. Orthologous to human ATG7 (autophagy related 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158252 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hza54 | Allele with one deletion | Unknown | Frameshift | CRISPR | |
| hza55 | Allele with one deletion | Unknown | Frameshift | CRISPR | |
| sa10973 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14235 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14768 | Allele with one point mutation | Exon 15 | Premature Stop | ENU | |
| sa35001 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa41752 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 31 | Alliance | Spinocerebellar ataxia, autosomal recessive 31 | 619422 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000594 | THIF-type NAD/FAD binding fold |
| Domain | IPR032197 | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal |
| Family | IPR006285 | Ubiquitin-like modifier-activating enzyme Atg7 |
| Family | IPR045886 | ThiF/MoeB/HesA family |
| Homologous_superfamily | IPR035985 | Ubiquitin-activating enzyme |
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Domain Details Per Protein
| Protein | Length | ThiF/MoeB/HesA family | THIF-type NAD/FAD binding fold | Ubiquitin-activating enzyme | Ubiquitin-like modifier-activating enzyme Atg7 | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2 |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QHT7
|
704 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:LOXP-mCherry-LOXP-atg7-Cerulean) |
| 1 | Wang et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | fb76g05 | ||
| Encodes | EST | IMAGE:7158252 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021479676 (1) | 3586 nt | ||
| Genomic | GenBank:FO704634 (1) | 37522 nt | ||
| Polypeptide | UniProtKB:A0A8M9QHT7 (1) | 704 aa |
- Tucker, S.K., Gosul, R., Swartz, M.E., Zhang, S., Eberhart, J.K. (2024) Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death. Development (Cambridge, England). 151(6):
- Zhu, P., Li, J., Yan, F., Islam, S., Lin, X., Xu, X. (2024) Allelic heterogeneity of TTNtv cardiomyopathy can be modeled in adult zebrafish. JCI insight. 9(7):
- Zhu, Y., Fujimaki, M., Snape, L., Lopez, A., Fleming, A., Rubinsztein, D.C. (2024) Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis. Nature cell biology. 26(4):542-551
- Wasilewska, I., Majewski, Ł., Adamek-Urbańska, D., Mondal, S.S., Baranykova, S., Gupta, R.K., Bielecki, D., Winata, C.L., Kuznicki, J. (2023) Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia. Zebrafish. 20:146159146-159
- Kong, S., Zhou, D., Fan, Q., Zhao, T., Ren, C., Nie, H. (2022) Salviae miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection Protects against Myocardial Ischemia-Reperfusion Injury and Heart Failure. Computational and Mathematical Methods in Medicine. 2022:7809485
- Liu, S., Hu, G., Luo, S., Wu, W., Zhou, Q., Jin, R., Zhang, Y., Ruan, H., Huang, H., Li, H. (2022) Insights into the evolution of the ISG15 and UBA7 system. Genomics. 114(2):110302
- Ren, Q., Jiang, X., Zhang, S., Gao, X., Paudel, Y.N., Zhang, P., Wang, R., Liu, K., Jin, M. (2022) Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 147:112629
- Wen, W., Sun, C., Chen, Z., Yang, D., Zhou, Z., Peng, X., Tang, C. (2022) Alcohol Induces Zebrafish Skeletal Muscle Atrophy through HMGB1/TLR4/NF-κB Signaling. Life (Basel, Switzerland). 12(8)
- Han, S.L., Qian, Y.C., Limbu, S.M., Wang, J., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2021) Lipolysis and lipophagy play individual and interactive roles in regulating triacylglycerol and cholesterol homeostasis and mitochondrial form in zebrafish. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(9):158988
- Lu, X., Lu, L., Gao, L., Wang, Y., Wang, W. (2021) Calycosin attenuates doxorubicin-induced cardiotoxicity via autophagy regulation in zebrafish models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 137:111375
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