FIGURE

Fig. 1

ID

ZDB-FIG-180828-29

Publication

Marsden et al., 2018 - A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold

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Fig. 1

The Startle Threshold Is Reduced in Mutants from the Forward Genetic Screen (A) Distribution of startle response frequency to 10 low-intensity (13.5 dB) stimuli in 5 dpf wild-type TLF larvae (black bars, n = 110) and larvae from a cross of triggerhappy^p400 carriers (red bars, n = 104). (B) Startle frequency for 10 trials at each of 6 intensities with sigmoidal fit curves. triggerhappy^p400 and TLF larvae were split into two groups: putative mutants (top 25%; p400, red line; TLF, black line) and putative siblings (bottom 75%; p400, pink line; TLF, gray line) based on their startle response frequency at 13.5 dB (mean ± SEM). (C) Startle sensitivity indices. The area under the curves in (B) are displayed for the top 25% of WIK and TLF (black circles and squares, mean ± SD) and 7 mutant lines (red triangles; p400-406; ∗∗∗∗p < 0.0001, one-way ANOVA with Dunnett’s multiple comparison test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cyfip2^p400/p400 unm_p401^p401/p401 unm_p402^p402/p402 unm_p403^p403/p403 unm_p404^p404/p404 unm_p404^p405/p405 unm_p404^p406/p406
Observed In:	sensory perception of sound startle response
Stage:	Day 5

Phenotype Detail

Acknowledgments

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