Fig. 2

CC receptors can control a process regulated by CXC receptors.

(A) Epifluorescence image of sox17::gfp transgenic control embryos (left panel) and embryos knock down for Cxcr4a. The Cxcr4a knocked down embryos were injected with control RNA (cntl) or with cxcr4a RNA, or co-injected with ccr9 RNA and its ligand ccl25 RNA. The quantitation of the endoderm displacement with respect to the forerunner cells is presented in the graph on the right. See also Figure 1—figure supplement 1. (B) Epifluorescence image of sox17::gfp transgenic control embryos (left panel) and of embryos knocked down for Cxcr4a. The embryos were injected with control RNA, with cxcr4a RNA, or co-injected with ccr7 RNA and its ligand ccl19 RNA. The quantitation of the endoderm displacement with respect to the forerunner cells is presented in the graph on the right. 0.8 pmol of each morpholino was used. 100 pg of receptor and 50 pg of ligand encoding mRNA was used, as well as equimolar amounts of control RNA.