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Fig. S3

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ZDB-FIG-180802-9

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Klatt Shaw et al., 2018 - Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling

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Fig. S3

RyR function is necessary for the Shh-dependent patterning of the neural tube. Related to Figure 2. (A and B) Development of motoneurons, but not Rohon Beard sensory neurons of the neural tube is diminished by azumolene treatment. Isl1 expression marks sensory Rohon Beard (arrow) and motor neurons (arrowhead) in 24hpf embryos. Rohon Beard neurons develop independently of Shh signaling. Scale bar indicates 25μm. (C and D) Gene expression domains in the neural tube are shifted along the dorsoventral axis in azumolene-treated or MZryr1a^(-/-);MZryr2a^(-/-);MZryr3^(-/-) embryos. Quantification of the dorsoventral extent of the nkx6.1 and pax3 expression domains. Each point represents a single embryo and the line indicates the mean. *p<0.01; **p<0.001; ***p<0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 45(4), Klatt Shaw, D., Gunther, D., Jurynec, M.J., Chagovetz, A.A., Ritchie, E., Grunwald, D.J., Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling, 512-525.e5, Copyright (2018) with permission from Elsevier. Full text @ Dev. Cell