FIGURE

Fig. 4

ID

ZDB-FIG-180713-38

Publication

Yan et al., 2018 - Activation of Hepatic Stellate Cells During Liver Carcinogenesis Requires Fibrinogen/Integrin αvβ5 in Zebrafish

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Fig. 4

Effects of manipulation of integrin αvβ5 activity on tumorigenesis. 3-dpi kras+ and WT larvae were treated cilengitide or ADP together with dox for 4 days. Liver size were measured and liver sections were stained for cell proliferation and apoptosis. More than 20 fish were analyzed in each group. (A) Gross morphology of larvae after 4 days of treatment (left lateral view). The WT livers were outlined. (B) Quantification of liver size. (C) IF staining of PCNA on liver sections. (D) Quantification of PCNA-positive cells in the liver. (E) IF staining of Caspase 3 on liver sections. (F) Quantification of Caspase 3-positive cells in the liver. Livers are marked by dash lines. Int indicates intestine. *P < .05. Scale bar: 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: ADP chemical treatment by environment: doxycycline chemical treatment by environment: doxycycline
Observed In:	liver liver apoptotic process liver cell population proliferation
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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