FIGURE

Fig. 3

ID

ZDB-FIG-180622-29

Publication

Missinato et al., 2018 - Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration

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Fig. 3

Increased cardiomyocyte proliferation and angiogenesis in dusp6 mutant hearts after cardiac injury. (A) Hearts at 7 dpa, immunostained for Mef2c (green; cardiomyocyte nuclei) and Pcna (red; proliferation marker). Cardiomyocyte proliferation is increased in dusp6 mutant hearts (n=23) compared with WT hearts (n=35). Arrowheads indicate proliferating cardiomyocytes. (B) Quantification of cardiomyocyte proliferation index in WT and dusp6 mutant hearts. ****P<0.0001, Student's t-test. (C) EGFP⁺ vessels were visualized in Tg(fli1a:EGFP)^y1; dusp6^pt30a/pt30a (n=16) and Tg(fli1a:EGFP)^y1 (n=10) hearts at 8 dpa. Dashed line demarcates the resection plane. (D) Quantification of new vessels formed inside the clot area of hearts at 8 dpa. **P<0.01, Student's t-test. Scale bars: 100 µm.

Expression Data

Antibody:	Ab1-mef2
Fish:	WT dusp6^pt30a/pt30a
Condition:	resection: cardiac ventricle
Anatomical Term:	cardiac muscle cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dusp6^pt30a/pt30a dusp6^pt30a/pt30a; y1Tg
Condition:	resection: cardiac ventricle
Observed In:	cardiac muscle cell cardiac muscle cell proliferation cardiac muscle tissue regeneration regenerating tissue angiogenesis
Stage:	Adult

Phenotype Detail

Acknowledgments

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