FIGURE

Fig. 2

ID

ZDB-FIG-180620-17

Publication

Auer et al., 2018 - Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging

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Fig. 2

Differences in Myelin Sheath Lengths Are Established within a Few Days after Their Initiation

(A) Timeline of confocal images of an olig1:memEYFP-labeled myelin sheath in a Tg(mbp:memCerulean) background between 5 and 12 days post-fertilization (dpf) getting flanked by two neighboring sheaths over the course of analysis (arrowheads). Scale bar, 10 μm.

(B) Timeline of confocal images as in A showing an individual sheath flanked by only one neighbor (arrowheads). Scale bar, 10 μm.

(D) Quantification of growth speeds of individual sheaths between 1 and 10 days post-initiation (dpi). Data are expressed as median with interquartile range (Wilcoxon matched-pairs signed-rank test, p < 0.001).

(E) Quantification of the relative length increase of sheaths with two, one, or no neighboring sheath by the end of analysis. Data are expressed as mean ± SD.

(F) Quantification of the relative length increase of sheaths initiated at 5 and 14 dpf, respectively. Data are expressed as mean ± SD.

(G) Correlation of sheath growth speed from 1 to 3 dpi with its length at 8 dpi.

See also Figure S2 and Movies S1 and S2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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