FIGURE

Fig. 3

ID

ZDB-FIG-180619-11

Publication

Gou et al., 2018 - sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish

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Fig. 3

Effect ofsox2-/-andsox3-/-on early placode size. (A-H) Expression of pax8 at 11 hpf (A-D) and pax2a at 12 hpf (E-H) in control embryos (A, E), sox2-/- mutants (B, F), sox3-/- mutants (C, G) and sox2-/-; sox3-/- double mutants (D, H). Dorsal views with anterior up (A-D) or dorsal-lateral views with anterior to the left (E-H). Scale bar (E-H), 100 µm. (I, J) Box-and-whisker plots of relative surface area of otic/epibranchial domain of pax8 (I) or pax2a (J) in control, sox2-/-, sox3-/- and sox2-/-; sox3-/- double mutant embryos. Data are normalized relative to control groups, with means indicated by green lines. Asterisks indicate statistically significant differences relative to control (*P<0.05, *** P<0.001, Tukey's HSD test). Brackets indicate comparisons between non-control groups. n.s., not significantly different.

Expression Data

Genes:	pax2a pax8
Fish:	AB sox2^x50/x50 (AB) sox3^x52/x52 (AB) sox2^x50/x50; sox3^x52/x52 (AB)
Anatomical Term:	otic placode
Stage Range:	1-4 somites to 5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sox2^x50/x50 (AB) sox3^x52/x52 (AB) sox2^x50/x50; sox3^x52/x52 (AB)
Observed In:	otic placode
Stage Range:	1-4 somites to 5-9 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 435(1), Gou, Y., Guo, J., Maulding, K., Riley, B.B., sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish, 84-95, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.