FIGURE

Fig. S3

ID

ZDB-FIG-180615-13

Publication

Brown et al., 2017 - Neuregulin-1 is essential for nerve plexus formation during cardiac maturation

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Fig. S3

Adult cardiovascular consequences in nrg1^z26, nrg1‐III specific allele. (A) Gross appearance of adult nrg1^WT and nrg1^z26/z26 fish. (B) Body mass normalized to standard length in adult fish SL 20±2, N=12. (C) Critical swimming speed of adult fish SL=15±1 N=8. (D) Weekly survival of nrg1^WT and nrg1^z26/z26 clutchmates reared separately in N=7 tanks of 10 fish each. (E‐F) Heart rate variance (HRV) and heart rate in beats per minute measured via electrocardiogram, SL=15±1, N=3–5. (G‐H) Representative electrocardiographs from nrg1^WT and nrg1^z26/z26 fish. (I) Representative z‐projections of confocal images anti‐acetylated α‐tubulin axon staining on the dorsal surface of SL 15 fish with the atrium removed. (J) Quantification of ventricle surface innervation as the quotient of the total length of axons and ventricle surface in N>3 hearts at SL 10±1, SL 15±1, and SL 17.5±1. Abbreviations a=atrium, v=ventricle, ba= bulbous arteriosus. Student's T‐test mutant compared to wild type. Error bars are S.E.M. ^P=0.05‐0.10, *P=0.01‐0.05, **P=0.001–0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell. Mol. Med.