FIGURE

Fig. S2

ID

ZDB-FIG-180221-19

Publication

Karttunen et al., 2017 - Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber

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Fig. S2

Oligodendrocyte ablation results in extensive myelin vacuolation.
A. Oligodendrocytes labelled with mbp:EGFP-CAAX in DMSO- or Mtz-treated Tg(mbp:mCherry-NTR) animals, before (top panel) or after (bottom panel) a two-day treatment with Mtz. Red arrowheads indicate putative myelin vacuoles.
A. Representative example of myelin vacuolation and disruption of spinal cord organisation, as visualised by the stable transgenic line Tg(mbp:EGFP-CAAX).
B. Brightfield images taken at 3dpt (top), where large vacuoles are clearly visible in the Mtz-treated animal (red arrowheads) and at 9dpt (bottom), when vacuoles are no longer detectible.
C. Representative electron micrographs of ventral hemi-spinal cords of DMSO- and Mtz-treated Tg(mbp:mCherry-NTR) animals. The control image shows the typical organisation of the spinal cord at this age, whereas the treated image contains numerous large fluid-filled vacuoles (labelled with red letters V) which disrupt the overall structure of the spinal cord.
Scale bars in A-B: 20μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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