FIGURE

Fig. 5

ID

ZDB-FIG-180105-5

Publication

Yang et al., 2017 - Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma

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Fig. 5

Effects of serotonin level and HSC activation on kras^V12-induced liver fibrosis. Three-month-old adult zebrafish were treated with dox with or without serotonin, BW23C86, PCPA, and SB204741 for 7 days. (A) IF staining of collagen I antibody and quantification of fibrotic liver tissue area in collagen I antibody–stained liver sections (n > 8 in each group). (B) Staining and quantification of fibrotic liver tissue area in Picrosirius Red–stained liver sections (n > 8 in each group). (C) Staining and quantification of fibrotic liver tissue area in Gomori’s trichrome–stained liver sections (n > 8 in each group). *P < .05. Scale bars: (A) 50 μm, and (B and C) 500 μm. DAPI, 4',6-diamidino-2-phenylindole.

Expression Data

Antibody:	Ab2-col1
Fish:	WT gz32Tg
Conditions:	chemical treatment by environment: doxycycline chemical treatment by environment: 4-chloro-L-phenylalanine chemical treatment by environment: serotonin
Anatomical Terms:	female organism liver liver male organism liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gz32Tg
Condition:	chemical treatment by environment: doxycycline
Observed In:	male organism liver
Stage:	Adult

Phenotype Detail

Acknowledgments

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