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Fig. S1

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ZDB-FIG-170927-14

Publication

Madigan et al., 2017 - A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy

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Fig. S1

M. leprae-Infected Macrophages Escape Circulation, Related to Figures 1G and 1H

(A) Confocal image from Figure 1G of a 4 dpf kdrl:dsRed larva, which has fluorescent blood vessels, 2 days post-infection (dpi) with fluorescent M. leprae; dashed lines define insets (1-4) shown in B. 10 μm bar.

(B) Monochannel and merged images of insets from A, showing M. leprae within cells, likely macrophages, which are visible by Nomarski microscopy. Arrows, intracellular M. leprae retained in vessels; arrowheads, intracellular M. leprae outside vessels. 10 μm bar.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Cell, 170, Madigan, C.A., Cambier, C.J., Kelly-Scumpia, K.M., Scumpia, P.O., Cheng, T.Y., Zailaa, J., Bloom, B.R., Moody, D.B., Smale, S.T., Sagasti, A., Modlin, R.L., Ramakrishnan, L., A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy, 973-985.e10, Copyright (2017) with permission from Elsevier. Full text @ Cell