FIGURE

Fig. S3

ID

ZDB-FIG-170907-21

Publication

Pfefferli et al., 2017 - The careg element reveals a common regulation of regeneration in the zebrafish myocardium and fin

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Fig. S3

careg:dmKO2 is transiently expressed in the peri-injured myocardium during heart regeneration.

(a-j) Immunofluorescence staining of careg:dmKO2;cmlc2:EGFP heart sections labelled with antibodies against GFP (cardiac cells, blue) and embCMHC (green) at different time points after cryoinjury. N=4. (a-b) At 4 dpci, careg:dmKO2+ CMs emerge along the wound margin. (c-f) At 7 and 14 dpci, a large proportion of careg:dmKO2+ CMs activates the expression of embCMHC. (g-h) At 30 dpci, careg:dmKO2 expression declines in the trabecular myocardium, but the primordial layer was not fully restored in the regenerated part of the ventricle. (i-j) At 90 dpci, the myocardium is completely regenerated, but the expression of careg:dmKO2 is not completely reestablished in the subcortical region. The arrowheads indicate the position of the gap in the subcorical layer.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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