FIGURE

Fig. S3

ID

ZDB-FIG-161129-20

Publication

Marro et al., 2016 - Collagen XII Contributes to Epicardial and Connective Tissues in the Zebrafish Heart during Ontogenesis and Regeneration

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Fig. S3

col12a1a-expressing cells accumulate at the site of injury at the onset of heart regeneration.

(A-K) In-situ hybridization of heart sections at early time points after cryoinjury with probes of two col12 paralogs (purple) followed by immunofluorescence staining against Tropomyosin (blue) and Col XII (green). (A-D) Uninjured hearts do not markedly express col12a1a, but col12a1b in the epicardium, which is surrounded by the Col XII deposition. (E-G) At 1 dpci, col12a1a-expressing cells cover the circumference of the injured heart, Col XII persists at the epicardium at the side of injury. (I-L) At 4 dpci, col12a1a- and col12a1b-expressing cells accumulate at the surface of the injury site. The gene expression correlates with the localization of Col XII protein.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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