FIGURE

Fig. 5

ID

ZDB-FIG-160826-15

Publication

Ji et al., 2016 - Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs

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Fig. 5

Tooth morphogenesis is disrupted in Pitx2HD mutants. (A-C) Ventral views of alizarin red staining of teeth at 5 dpf in wild-type (A), pitx2HD^sny7/sny7 (B) and pitx2c^sny3/sny3 (C) fish. c5: fifth ceratobranchial; 4V¹, 3V¹ and 5V¹ designate individual teeth. (D) Quantification of tooth defects observed in pitx2HD^sny7 and pitx2c^sny fish at 5 dpf. Tooth malformations were defined as a reduced number of teeth and incomplete tooth formation as shown in (B).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pitx2^sny3/sny3 (AB/TU) pitx2^sny7/sny7 (AB/TU)
Observed In:	ceratobranchial 5 cartilage ceratobranchial 5 primary tooth odontogenesis tooth 3V tooth 4V tooth 5V
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 416(1), Ji, Y., Buel, S.M., Amack, J.D., Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs, 69-81, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.