FIGURE

Fig. T4

ID

ZDB-FIG-160804-16

Publication

Houbrechts et al., 2016 - Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function

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Fig. T4

Relative rod and cone photoreceptor number in D1D2MO and D3bMO zebrafish at 4 and 7 dpf. Data represent relative cone/rod numbers per retinal surface area (expressed as number ×10^-3/pixel²) and are shown as mean ± SEM (n ≥ 5 per group). The following antibodies were used: Zpr1 (green and red cones), anti-blue opsin (blue cones), anti-UV opsin (UV cones) and Zpr3 (rods). Rod data were obtained in a separate experiment and only counted at 4 dpf. For a given opsin and stage groups with no common letter are significantly different (p < 0.05). Data followed Gaussian distribution and were analyzed by one-way ANOVA with Tukey post hoc test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WIK + MO1-dio3b WIK + MO1-dio1 + MO1-dio2
Knockdown Reagents:	MO1-dio1 MO1-dio2 MO1-dio3b
Observed In:	retinal cone cell retinal photoreceptor layer retinal photoreceptor layer blue sensitive photoreceptor cell retinal photoreceptor layer green sensitive photoreceptor cell retinal photoreceptor layer red sensitive photoreceptor cell retinal photoreceptor layer UV sensitive photoreceptor cell retinal rod cell
Stage Range:	Day 4 to Days 7-13

Phenotype Detail

Acknowledgments

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Reprinted from Molecular and Cellular Endocrinology, 424, Houbrechts, A.M., Vergauwen, L., Bagci, E., Van Houcke, J., Heijlen, M., Kulemeka, B., Hyde, D.R., Knapen, D., Darras, V.M., Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function, 81-93, Copyright (2016) with permission from Elsevier. Full text @ Mol. Cell. Endocrinol.