FIGURE

Fig. 9

ID

ZDB-FIG-160728-9

Publication

McCarthy et al., 2016 - An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull

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Fig. 9

Postchordal neurocranial development does not require brachury function or a notochord. Anterior is to the left in all panels. (A-B, A′-B′) hyaluronan synthetase 2 (has2) is expressed in cephalic regions at 10 h post-fertilization (hpf) in both wildtypes and brachury mutants. (C and D) The late chondrogenic marker col2a1a at 24 hpf appears in both brachury mutants and siblings in the forming postchordal area of the developing embryo (compare D to C, arrowhead in C denotes anterior notochord). (E and F) At 5 days post-fertilization, postchordal neurocrania of brachury mutants are normal, sans notochord, compared to siblings (compare F to E). scale bar=50 µm in A and 10 µm in A′ and C and 20 µm in E.

Expression Data

Genes:	col2a1a has2
Fish:	AB tbxta^b195/b195
Anatomical Terms:	chondrocyte mesoderm anterior region
Stage Range:	Bud to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tbxta^b195/b195
Observed In:	neurocranium posterior region notochord
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 415(2), McCarthy, N., Sidik, A., Bertrand, J.Y., Eberhart, J.K., An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull, 261-77, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.