FIGURE

Fig. 4

ID

ZDB-FIG-160705-5

Publication

Lin et al., 2016 - Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis

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Fig. 4

Characterization of the function of LPA₃ during primitive erythropoiesis in zebrafish embryos.

Zebrafish embryos were immersed in (a) the LPA_1/3 antagonist Ki16425 or (b) the LPA₃ agonist 2S-OMPT for 48 h. O-dianisidine staining was classified as normal, moderate, or severe based on the expression level of embryonic blood in the CHT region. The right-hand panel shows the quantitative results. (c) Whole-mount in situ hybridization showed the mRNA expression of α-A1, β-E1 globin and ikaros in zLPAR₃ tMO-injected or wild type embryos.

Expression Data

Genes:	hbaa1 hbbe1.1 ikzf1
Fish:	WT WT + MO2-lpar3
Knockdown Reagent:	MO2-lpar3
Anatomical Terms:	myeloid cell nucleate erythrocyte
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment: KI16425
Observed In:	hemoglobin biosynthetic process
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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